Ciro Dantas Soares
University of Campinas, Brazil
Title: In vivo experimental models of wound healing under the influence of photobiomodulation therapy
Biography
Biography: Ciro Dantas Soares
Abstract
Photobiomodulation therapy (PBMT) is the most recent term for the Low-Level Light Th erapy in the MeSH data. As stated by Anders et al. photobiomodulation is defi ned as “A form of light therapy that utilizes non-ionizing forms of light sources, including lasers, LEDs and broadband light, in the visible and infrared spectrum. It is a nonthermal process involving endogenous chromophores eliciting photophysical (i.e. linear and nonlinear) and photochemical events at various biological scales. This process results in benefi cial therapeutic outcomes including but not limited to the alleviation of pain or infl ammation, immunomodulation and promotion of wound healing and tissue regeneration”. The use of PBMT in wound healing lacks mechanistic in vivo assays to determine the pathways activated during the diff erent phases of repair. We will present new data regarding the expression of fi broblast growth factors (FGF) under skin and bone wounds treated with various sources of PBMT. It was demonstrated that PBMT modulates the levels of basic FGF, particularly and consequently, acts activating important pathways of angiogenesis, cell survival and proliferation in models of skin and bone wound healing. In addition, PBMT improves bone repair in female rats with osteoporosis by decreasing the number of neutrophils, monocytes and osteoclast. In summary, the modulation of FGF2 seems to be an important step in the PBMT-based repair and also PBMT improves wound healing by enhancing neocollagenesis, increasing the number of new vessels formed in the tissue (neoangiogenesis) and modulating matrix metalloproteinase-2 expression and as expected, PBMT stimulated bone repair in female rats with osteoporosis and slightly decreased the infl ammatory response.